Indinavir: what it does, who used it, and what to watch for

Indinavir (brand name Crixivan) is an HIV protease inhibitor that used to be a mainstay of treatment. Today it’s less common because newer drugs work better and cause fewer problems. Still, you may run into it in older treatment histories or in places where newer meds aren’t available. Here’s a clear, practical guide so you know what indinavir does, the real risks, and simple safety steps you can use right away.

Quick facts and how it works

Indinavir blocks an enzyme called protease that HIV needs to make new virus particles. That lowers viral load and helps immune cells recover. Typical dosing historically was 800 mg every 8 hours when used alone. With a low dose of ritonavir (a booster), dosing can be reduced to twice daily — but only a clinician should change your schedule.

Why boosting matters: ritonavir slows indinavir breakdown, so you get higher drug levels and fewer daily doses. That sounds good, but boosting changes the side effect and drug interaction picture, so your prescriber must manage it.

Safety, side effects, and practical tips

Biggest safety issue: kidney stones. Indinavir can crystallize in urine. Drink plenty of water — aim for about 1.5–2 liters a day unless your doctor says otherwise. If you get sudden flank pain, blood in the urine, or trouble peeing, call your clinic right away.

Other common problems: increased bilirubin (yellowing skin or eyes), nausea, headaches, changes in blood sugar, and body fat redistribution (lipodystrophy). Your provider will check kidney function, liver tests, glucose, and lipids before and during treatment.

Drug interactions are a frequent headache. Indinavir is handled by CYP3A4 in the liver. That means many meds raise or lower indinavir levels — from some statins and certain antibiotics to herbal products like St. John’s wort. Always tell your doctor every medicine and supplement you take.

If you’re pregnant, breastfeeding, or have kidney disease, talk to an HIV specialist. Safer, better-studied alternatives usually exist.

Thinking about buying indinavir online? Be cautious. Only use pharmacies that accept a valid prescription, list a real address and phone number, and are licensed in their country. Avoid sites that sell prescription meds with no Rx, offer prices that are absurdly low, or use unclear shipping and privacy policies. When in doubt, ask your clinic for a recommended pharmacy.

Short practical checklist:

• Keep hydrated to lower stone risk.
• Bring a full med list to every appointment.
• Get baseline kidney and liver tests, plus glucose and lipids.
• Report flank pain, dark urine, or jaundice right away.
• Prefer newer HIV drugs if available — they’re usually safer and simpler.

If you have a specific question about indinavir — dosing with other meds, lab targets, or switching to newer therapy — mention it and I’ll cover that next.