Motrin side effects: what to watch for and how to stay safer

Motrin (ibuprofen) is a common over-the-counter pain reliever. It works well for headaches, muscle pain, fever, and period cramps. But like any medicine, Motrin can cause side effects. Knowing the likely ones and the rare but serious ones helps you use it safely.

Common, mild side effects

The things most people notice are stomach upset, heartburn, nausea, and mild headache or dizziness. You might also get mild swelling, a rash, or temporary ringing in the ears. These usually go away if you stop the medicine or lower the dose. Take Motrin with food or milk to cut down on stomach irritation.

Serious side effects to act on

Rare but dangerous problems include stomach bleeding or ulcers, severe allergic reactions, kidney damage, and increased risk of heart attack or stroke—especially with long-term use or high doses. Warning signs to get medical help fast are black or bloody stools, severe belly pain, sudden shortness of breath, chest pain, sudden weakness or slurred speech, high fever, or swelling of the face and throat.

People with existing heart disease, high blood pressure, kidney problems, or a history of stomach ulcers have a higher chance of serious issues. Older adults are more sensitive to side effects. Pregnant people in the third trimester should avoid Motrin because it can harm the baby and affect labor.

Check for drug interactions. Motrin can reduce the effect of some blood pressure medicines (like ACE inhibitors and diuretics), increase bleeding risk with blood thinners (warfarin), and interact with lithium or methotrexate. Don’t mix with other NSAIDs (aspirin, naproxen) unless your doctor says it’s okay.

How to lower your risk: use the lowest effective dose for the shortest time. Read labels—many cold or flu products include ibuprofen. Avoid alcohol while taking Motrin because it raises the chance of stomach bleeding. If you need daily pain control, talk to your doctor about safer long-term options.

For kids, use the dosing on the label or ask a pharmacist—dosing depends on weight. Never give adult-strength doses to children.

If you notice mild side effects, stop the medicine and see if symptoms improve. For severe signs listed above, call emergency services right away. If you take Motrin regularly, get periodic checkups—your doctor may check blood pressure and kidney function.

Short tip: keep a list of all medicines you take and tell your provider you use Motrin. That simple step helps prevent dangerous interactions and ensures you get the safest care for pain or fever.